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Intensification of Diethyl Methylphosphite Synthesis Based on Kinetics Study and CFD Modeling

AICHE JOURNAL(2024)

Tsinghua Univ

Cited 0|Views12
Abstract
A "pre-dissolving ammonia" intensification method for continuous production of diethyl methylphosphite (DEMP) was proposed based on kinetics study of methyl dichlorophosphine (MDP) substitution and DEMP acidolysis. The method was verified in a continuous synthesis system consisting of a small jet reactor. Compared with the selectivity of similar to 80% obtained in a stirred flask, the selectivity reached 98% by the intensification method. Eliminating the resistance of gas-liquid mass transfer and enhancement of mixing enabled rapid removal of the produced HCl, thus, the DEMP selectivity was greatly increased. The high DEMP selectivity obtained was insensitive to reaction temperature, reactor size and ammonia to chlorine ratio in the studied range. A computational fluid dynamics (CFD) model was proposed for this liquid turbulent reactive flow. Numerical simulations revealed that HCl could be removed rapidly by the neutralization reaction, which was limited by micromixing efficiency. The CFD simulation further indicates the feasibility of "pre-dissolving ammonia" for industrial production.
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CFD simulations,diethyl methylphosphite,process intensification,reaction kinetics
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要点】:本文提出了一种基于动力学研究和计算流体动力学(CFD)模型优化的“预溶解氨”强化方法,显著提高了连续生产二乙基甲基膦酸酯(DEMP)的选择性至98%。

方法】:通过研究甲基二氯化磷(MDP)取代反应和DEMP酸解反应的动力学,提出了“预溶解氨”强化方法,并在小型喷射反应器中进行了验证。

实验】:实验在连续合成系统中进行,使用小型喷射反应器,通过消除气-液传质阻力和增强混合效率,实现了快速移除生成的HCl,从而大幅提高了DEMP的选择性。CFD模型用于模拟液体湍流反应流动,模拟结果证实了“预溶解氨”方法在工业生产中的可行性。