Interaction of Blood and Bacteria with Slippery Hydrophilic Surfaces

Slippery surfaces (i.e., surfaces that display high liquid droplet mobility) are receiving significant attention due to their biofluidic applications. Non-textured, all-solid, slippery hydrophilic (SLIC) surfaces are an emerging class of rare and counter-intuitive surfaces. In this work, the interactions of blood and bacteria with SLIC surfaces are investigated. The SLIC surfaces demonstrate significantly lower platelet and leukocyte adhesion (approximate to 97.2% decrease in surface coverage), and correspondingly low platelet activation, as well as significantly lower bacterial adhesion (approximate to 99.7% decrease in surface coverage of live Escherichia Coli and approximate to 99.6% decrease in surface coverage of live Staphylococcus Aureus) and proliferation compared to untreated silicon substrates, indicating their potential for practical biomedical applications. The study envisions that the SLIC surfaces will pave the path to improved biomedical devices with favorable blood and bacteria interactions. The interactions of blood and bacteria on an emerging class of counter-intuitive slippery hydrophilic (SLIC) surfaces are investigated. The SLIC surfaces demonstrate significantly lower adhesion with live blood cells (i.e., platelets & leukocytes), Escherichia Coli (i.e., gram-negative bacteria), and Staphylococcus Aureus (i.e., gram-positive bacteria). The study envisions that the SLIC surfaces will pave the path to improved biomedical devices.image