Self-Assembled Poly(rosmarinic acid) Nanoantioxidant for Enhanced Acute Liver Injury Treatment

Drug-based backboned polymers, especially poly(drug monomer) cross-linked with dynamic chemical bonds, have emerged as nanomedicines with reduced excipients. In this research, rosmarinic acid, a natural antioxidant with therapeutic potential for acute liver injury, was polymerized through borated ester bonds, and the linear poly(rosmarinic acid) (PRA) self-assembled into nanomedicines (named PRA NPs) through hydrophobic interactions in the presence of hydrophobic glycerol monooleate. Due to the fast and efficient liver accumulation, PRA NPs increased the antioxidation potential of rosmarinic acid and demonstrated better therapeutic effects in the in vivo treatment of acute liver injury. The findings of this study indicate that borate ester bond-mediated backbone poly(drug monomer) polymeric nanomedicines could provide a new approach for the processing of versatile nanomedicines.