A simple endogenous zinc-activated and accumulated nanocluster platform for memory immunotherapy of spinal cord injury

Chang Xu,He Tian,Haosen Zhao,Huicong Feng,Jiachen Sun,Zipeng Zhou,Yue Guo,Zhanpeng Guo,Yajiang Yuan,Chuanjie Zhang,Dan Li,Xifan Mei

MATERIALS & DESIGN（2023）

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摘要

•GSH-AuNCs were found to accumulate endogenous zinc in the injured spinal cord.•A new mechanism based on the accumulation of endogenous zinc in the treatment of SCI was proposed.•Endogenous zinc accumulation stimulates immunotherapy.•R. The proposed treatment has memory therapeutic effects.

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关键词

Spinal cord injury,GSH-AuNCs,Zinc activation/accumulation,Memory immunotherapy,Low-toxic,Long-term drug dependence

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