Gold Self-Relay Catalysis Enabling Nazarov Cyclization/1,6-Addition Cascade Toward Functionalized Cyclopentenones

An efficient synthetic approach for the synthesis of cyclopentenones containing a C–C stereocenter that relies on gold(I)-catalyzed Nazarov-type cyclization/1,6-addition of 1,3-enyne esters with p-quinone methides (p-QMs) is described. This tandem transformation exhibited a satisfactory substrate scope and passable functional group compatibility, providing a novel protocol for rapid assembly cyclopentenones in good to excellent yields under mild reaction conditions.