Development of Tamarind Gum/ß-Cd-co-poly (MAA) Hydrogels for Ph-Driven Controlled Delivery of Capecitabine

A novel N,N methylene-bis-acrylamide (MBA) crosslinked tamarind gum and ss-cyclodextrin graft-poly(methacrylic acid) (TG/ss-CG-g-MAA) hydrogel was formulated for colon targeting. The swelling capability, mechanical strength, sol-gel fraction (%), in vitro release and in vivo toxicological screening were estimated experimentally. The effect of polymers, monomer and crosslinker on percentage drug loading, swelling and drug release was determined. TG/ss-CD-g-MAA hydrogel was characterized by FTIR, thermal analysis, X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM). Swelling was significant at pH 7.4 as compared to pH 1.2. Drug release studies showed that release was significant at pH 7.4 as compared to pH 1.2. Developed hydrogels were porous, thermally stable, offered uniform distribution of amorphous drug and pH-dependent capecitabine release in controlled fashion. Kinetic modelling revealed zero-order drug release and Korsmeyer-Peppas model mechanism of release. Lastly, TG/ss-CD-g-MAA hydrogel (F11) can act as prospective pH-responsive carrier for colon targeting. [GRAPHICS.]