Adjusted vascular contractility relies on integrity of progranulin pathway: Insights into mitochondrial function.

Shubhnita Singh,Ariane Bruder-Nascimento,Rafael M Costa,Juliano V Alves,Sivakama Bharathi,Eric S Goetzman,Thiago Bruder-Nascimento

bioRxiv : the preprint server for biology（2023）

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摘要

Our findings suggest that PGRN preserves the vascular contractility via regulating mitophagy flux, mitochondrial complex I activity, and redox signaling. Therefore, loss of PGRN function appears as a pivotal risk factor in CVD development.

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