Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model.

Xia Qiu,Hedong Zhang,Zhouqi Tang,Yuxi Fan,Wenjia Yuan,Chen Feng,Chao Chen,Pengcheng Cui,Yan Cui,Zhongquan Qi,Tengfang Li,Yuexing Zhu, Liming Xie,Fenghua Peng,Tuo Deng,Xin Jiang,Longkai Peng,Helong Dai

Chinese medical journal（2023）

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摘要

HHT promotes Treg cell differentiation and enhances Treg suppressive function by attenuating the TCR signaling pathway and upregulating the expression of Treg signature genes and IL-10 levels, thereby promoting mouse heart allograft acceptance. These findings may have therapeutic implications for organ transplant recipients, particularly those with viral infections and malignancies, which require a more suitable anti-rejection medication.

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