Nonequilibrium indicator for the onset of epileptic seizure.

The occurrence of spontaneous bursts of uncontrolled electrical activity between neurons can disrupt normal brain function and lead to epileptic seizures. Despite extensive research, the mechanisms underlying seizure onset remain unclear. This study investigates the onset of seizures from the perspective of nonequilibrium statistical physics. By analyzing the probability flux within the framework of the nonequilibrium potential-flux landscape, we establish a connection between seizure dynamics and nonequilibrium. Our findings demonstrate that the degree of nonequilibrium is sensitive to the onset of epileptic seizures. This result offers an alternative perspective on assessing seizure onset in epilepsy.