Modeling of postprandial glycemic response by consecutive reaction kinetics model for precise glycemic control

Objective The dynamics of postprandial glycemic response are crucial for human health, while there is currently a lack of efficient models that can capture its fine features. Methods To address this gap, a physiologically relevant model based on consecutive reaction kinetics (CRK) was developed in this study to describe human postprandial glycemic response dynamics. Results The model yielded robust fittings for both simulated and experimental glycemic data (comprising 134 datasets), and demonstrated flexibility in capturing the fine features of glycemic responses to a wide range of real foods, such as blood glucose rising and dropping rates. Conclusion The CRK model developed in this study should be applied in the future together with food and personal information to better understand the determinants of the variance of human postprandial glycemic response dynamics.