Mn2+-doped hollow mesoporous Prussian blue nanocubes for tumor synergistic therapy

To leverage the exceptional biomedical properties of Prussian blue (PB), we synthesized Mn2+-doped hollow mesoporous Prussian blue nanocubes (Mn-HMPB) via a straightforward ion-exchange method to enhance the photothermal/chemo synergistic therapeutic efficiency. The precise modulate of nanostructures of Mn-HMPB with notable photothermal conversion efficiencies and quercetin (QUE) loading capacities. Introducing Mn2+ doping in Mn-HMPB enables pH-responsive drug release under different physiological conditions. The systematic in vitro experiments have verified that the drug release and NIR irradiation mediated by Mn-HMPB@QUE nanocubes significantly inhibit the proliferation of Hela cells, resulting in an exceptional synergistic therapeutic outcome compared to single Mn-HMPB nanocubes or free QUE. Moreover, Mn-HMPB nanocubes exhibits outstanding biocompatibility and stability in psychological environment, positioning it as a reliable nano medicine candidate. In conclusion, this study findings demonstrate the effective inhibition of growth and metastasis of Hela cells by Mn-HMPB@QUE nanocubes, exhibiting their potential as a versatile nanoplatform for tumor therapy.