Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy

Kyle r. Cowdrick,Mariam Akbar, Tisha Boodooram, Labeausha h. Harris,Shasha Bai,Rowan o. Brothers, Michael Arrington,Seung yup Lee, Kirsma Khemani,Beatrice Gee,Erin m. Buckley

BIOMEDICAL OPTICS EXPRESS(2023)

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摘要
Cerebrovascular reactivity (CVR), defined as the ability of cerebral vasculature to dilate in response to a vasodilatory stimulus, is an integral mechanism in brain homeostasis that is thought to be impaired in sickle cell disease (SCD). This study used diffuse correlation spectroscopy and a simple breath-hold stimulus to quantify CVR non-invasively in a cohort of 12 children with SCD and 14 controls. Median [interquartile range] CVR was significantly decreased in SCD compared to controls (2.03 [1.31, 2.44] versus 3.49 [3.00, 4.11] %/mmHg, p = 0.028). These results suggest DCS may provide a feasible means to routinely monitor CVR impairments in pediatric SCD.
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