Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy

Bod et al.1 recently published a study in Nature that garnered attention to B cell- associated anti-tumor immunity and immunotherapy of melanoma and other tumors1. As a promising supplemental immunotherapy to mainstream methods that target T and natural killer (NK) cells, B cell-associated anti-tumor immunotherapy is promising, especially for patients who have failed treatment or are resistant to immune checkpoint inhibitors. Knowledge pertaining to B cell functions and associations with tertiary lymphoid structures (TLSs) requires further investigation to provide a thorough understanding of their roles in tumor immunity. The perspective herein focused on B cell roles in TLSs and associated anti-tumor activities to facilitate clinical application of this new treatment option.