Classification of Clinically Significant Prostate Cancer using Raman Spectroscopy and Support Vector Machine Classification

S.J. Van Breugel, I. Low, M.L. Christie, M.R. Pokorny, H.U. Holtkamp, M.K. Nieuwoudt,M.C. Simpson, K. Zargar-Shoshtari, C. Aguergaray

2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)(2023)

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摘要
Prostate cancer (PCa) is a significant healthcare problem in many western countries [1]. The current gold standard for diagnosis of PCa involves a highly invasive systematic transrectal or transperineal tissue biopsy. A growing part of the clinical community now recognises the interest of early diagnosis of clinically relevant cancers (ISUP grade 2, Gleason patterns (GP) 4 and higher) against ISUP1 tissue. ISUP1, consisting of only GP3, has a relatively indolent course, with cancer-specific deaths or metastases occurring in less than 1% of men [2]. Despite optimized utilization of mpMRI, the incidence of negative or clinically non-significant PCa following prostate biopsy remains very high (47% in our cohort). Earlier cancer grading and more accurate, targeted biopsies could help avoid unnecessary suffering, morbidity, and over-treatment for men with an ISUP1 diagnosis.
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cancer-specific deaths,clinical community,clinically relevant cancers,clinically significant prostate cancer,current gold standard,early diagnosis,Gleason patterns 4,GP3,growing part,highly invasive systematic transrectal,ISUP grade,ISUP1 diagnosis,ISUP1 tissue,metastases,nonsignificant PCa,prostate biopsy,raman spectroscopy,relatively indolent course,significant healthcare problem,support vector machine classification,targeted biopsies,transperineal tissue biopsy,western countries
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