Gene expression changes in the cerebellum are associated with persistent post-injury pain in adolescent rats exposed to early life stress

Neurobiology of Pain(2023)

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摘要
•Pain outcomes and cerebellar gene expression were examined in adolescent rats.•Similar behavioural pain outcomes were found in male and female rats following injury.•Injury and stress manipulations reduced cerebellar expression of genes relevant to stress and neurotransmission.•Injury and stress-dependent changes in gene expression were often sexually dimorphic.•There is a link between injury-induced changes in pain and gene expression in the cerebellum.
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关键词
cerebellum,stress,adolescent rats,pain,post-injury
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