Normalizing Input–Output Relationships of Cancer Networks for Reversion Therapy (Adv. Sci. 24/2023)

Cancer Reversion A genetic alteration can disrupt input-output relationship of the intracellular regulatory network within a cancer cell. However, by making use of the inherent redundancy remained in the complex network, we can still restore the input-output relationship through regulation of a proper molecular target and induce cancer reversion. More details can be found in article number 2207322 by Jae Il Joo, Hwa-Jeong Park, and Kwang-Hyun Cho.