A Multi-FPGA Implementation of FM-Index Based Genomic Pattern Search

FPGA clusters that consist of multiple FPGA boards have been gaining interest in recent times. Massively parallel processing with a stand-alone heterogeneous FPGA cluster with SoC-style FPGAs and mid scale FPGAs is promising with cost-performance benefit. Here, we propose such a heterogeneous FPGA cluster with FiC and M-KUBOS cluster. FiC consists of multiple boards, mounting middle scale Xilinx's FPGAs and DRAMs, which are tightly coupled with high-speed serial links. In addition, M-KUBOS boards are connected to FiC for ensuring high IO data transfer bandwidth. As an example of massively parallel processing, here we implement genomic pattern search. Next-generation sequencing (NGS) technology has revolutionized biological system related research by its high-speed, scalable and massive throughput. To analyze the genomic data, short read mapping technique is used where short Deoxyribonucleic acid (DNA) sequences are mapped relative to a known reference sequence. Although several pattern matching techniques are available, FM-index based pattern search is perfectly suitable for this task due to the fastest mapping from known indices. Since matching can be done in parallel for differ-ent data, the massively parallel computing which distributes data, executes in parallel and gathers the results can be applied. We also implement a data compression method where about 10 times reduction in data size is achieved. We found that a M-KUBOS board matches four FiC boards, and a system with six M-KUBOS boards and 24 FiC boards achieved 30 times faster than the software based implementation.