A Large-Pore Mesoporous Au@Pt@Rh Trimetallic Nanostructure with Hyperthermia-Enhanced Enzyme-Mimic Activities for Immunomodulation-Improved Tumor Catalytic Therapy

Guoqiang Song,Xinyue Shao,Chang Qu,Donghong Shi, Ran Jia,Yafei Chen,Jinping Wang,Hailong An

CHEMICAL ENGINEERING JOURNAL（2023）

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摘要

•Immunomodulatory nanozyme is proposed for improved tumor catalytic therapy.•Mesoporous Au@Pt@Rh nanozyme with hyperthermia enhanced POD-/CAT-like activities.•Au@Pt@Rh nanozyme catalyzes endogenous H2O2 into O2 and toxic ·OH.•Large porous cavities of Au@Pt@Rh increase the loading efficiency of LY.•LY and produced O2 raise M1 macrophages to promote the generation of H2O2.

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关键词

Trimetallic nanozyme,Large-pore mesoporous nanostructure,Hyperthermia,Immunomodulation,Tumor catalytic therapy

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