An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies

Jing Wang,Yuqi Wen,Yixin Zhang,Zhongming Wang, Yuyang Jiang,Chong Dai,Lianlian Wu,Dongjin Leng,Song He,Xiaochen Bo

Journal of advanced research（2023）

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摘要

KDDSL open the black box of neural network to achieve interpretable prediction of SL (The two shields represent two SL genes). This can help us utilize SL to kill cancer cell.

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关键词

Synthetic lethality,Combination therapy,Knowledge-driven,Data-driven,Artificial intelligence

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