Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL. Camille Laurent , Alina Nicolae , Cécile Laurent , Fabien Le Bras , Corinne Haı̈oun , Virginie Fataccioli , Nadia Amara , José Adélaı̈de , Arnaud Guillé , Jean‐Marc Schiano , Bruno Tesson , Alexandra Traverse-Gléhen , Marie‐Pierre Chenard , Lénaïg Mescam , Anne Moreau , Catherine Chassagne‐Clément , Joan Somja , Frédéric Escudie , Marc André , Nadine Martin , Laetitia Lacroix , François Lemonnier , Anne-Sophie Hamy , Fabien Reyal , Marie Bannier , Lucie Obéric , Naïs Prade , François-Xavier Frénois , Asma Beldi‐Ferchiou , Marie‐Hélène Delfau‐Larue , Réda Bouabdallah , Daniel Birnbaum , Pierre Brousset , Luc Xerri , Philippe Gaulard Blood（2019）
摘要
Key Points An accumulation of alterations in epigenetic modifiers and genes in the JAK/STAT pathway likely drives BI-ALCL oncogenesis. Whole exome sequencing of a large series of BI-ALCL demonstrates recurrent mutations in epigenetic regulators.
更多 查看译文
关键词
alcl, gene alterations, epigenetic modifiers, breast, jak-stat, implant-associated
AI 理解论文
溯源树
样例
