Inside Back Cover: Small‐molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual‐inhibiting properties for bladder cancer treatment (EXP2 5/2023)

Overexpression of the EGFR is found in up to 74% of bladder cancer tissue. Two natural products that were found, triptolide (represented by lightning) and hesperidin (represented by orange), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles (represented by oranges containing lightning), which not only remarkably improved their bioavailability and therapeutic but also reduced their systemic toxicity.