Enhancing Apoptosome Assembly via Mito‐Biomimetic Lipid Nanocarrier for Cancer Therapy (Adv. Funct. Mater. 46/2023)

Mito-Biomimetic Lipid Nanocarriers In article number 2305316, Shiqi Wang, Wenguo Cui, Hélder A. Santos, and co-workers show that when cytochrome C and lonidamine co-loaded liposomes enter breast cancer cells, they release the cytochrome C out, which binds with Apaf-1 protein and then assembles into apoptosomes. Since the binding of Cytochrome C and Apaf-1 is prevented by high intracellular ATP levels, the glycolysis inhibitor lonidamine can then reduce ATP and sensitize cytochrome C-induced apoptosome assembly and lead to apoptosis.