Mesoporous Bioactive Glass Nanoparticles with Biomineralization Activity for Surgical Hemorrhage Control

ABSTRACTBioactive glass nanoparticles (BGNs) are good bioactive materials for clinical treatment because of their unique composition and silica-oxygen network structure. Herein, we designed and reported a monodisperse mesoporous bioactive glass nanoparticle with biomineralization activity for surgical hemorrhage control. The results indicated that the BGNs have excellent biomineralization ability. In vivo and in vitro hemostasis studies suggested that BGNs have superior hemostatic properties to GZ (gauze) and GS (commercial gelatin sponge) and validated in vitro thrombosis, platelet adhesion, cytocompatibility and blood compatibility. The particles activated both endogenous and exogenous physiological coagulation pathways and could activate platelets and release Ca2+ to participate in the clotting pathway. Besides, the BGNs have good biocompatibility in vivo. These findings demonstrated that the potential of small diameter mesoporous bioactive glass nanoparticles is likely useful for bleeding control as potential hemostatic agents.