A10749 Relationship between arterial stiffness and diastolic dysfunction in primary hypertensive patients

Objectives: Left ventricular (LV) diastolic dysfunction often occurs with advanced age, hypertension, and diabetes, which are all associated with an increased arterial stiffness. This could prompt the possible occurrence of homologous changes at the cardiac and arterial level, leading to arterial-myocardial stiffening. Over the last 10 years, there have been a number of studies focusing on arterial stiffness and diastolic function in hypertensive patients, but only a few made use of the “gold standard” carotid-femoral pulse wave velocity (cf-PWV) as the parameter assessing arterial stiffness. The aim of the study is to investigate the association between arterial stiffness and LV diastolic function in primary hypertensive patients. Methods: Untreated primary hypertensive patients were recruited in Peking University First Hospital, Beijing, China from Novermber 2017 to February, 2018. Carotid-femoral pulse wave velocity (PWV) was assessed by means of PulsePen WPP001-ET system (Diatecne S.R.L Italy). LV diastolic function was evaluated by echocardiography. Results: 38 patients toke both cf-PWV and echocardiography evaluation, age 51.2 ± 14.1, among them 50% were female. Cf-PWV were 8.7 ± 1.4 m/s. Parameters of LV diastolic function were LV mass index (127.6 ± 31.8 g/m2), E(81.0 ± 19.6 cm/s), E/A(1.1 ± 0.4), e’(average of septal and lateral)(8.5 ± 2.3), and LV longitudinal strain rate (SR)(−20.1 ± 3.2%). Single factor analysis showed cf-PWV was associated with age, gender and e’. But after adjusted age, gender, BMI, MAP, HR, there was obvious correlation between cf-PWV and e’. Conclusion: In this small cohort study in untreated primary hypertensive patients, there was no significant relationship between parameters of arterial stiffness and LV diastolic function.