Intratumoral H₂O₂-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

H2O2-triggered release of CO: an intratumoral H2O2-responsive nanomedicine is constructed by effectively encapsulating the hydrophilic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize selective killing of tumor cells, exhibiting high in vitro and in vivo efficacies of CO gas therapy.