Palladates of the [NHC?H][Pd(NH₂)(CC)Cl₂] Type as Effective Pre-catalysts for the Formation of C-C and C-N Bonds

The environmentally friendly, simple synthesis of a family complexes of the general formula [NHC & sdot;H][Pd(NH2)(CC)Cl-2] (CC=biphenyl) is presented. The catalytic activity of these air- and moisture-stable complexes was evaluated as a function of the imidazolium counterion. These pre-catalysts can be converted, under catalytic conditions, to Pd-NHC species enabling the Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig amination reactions under very mild operating conditions.