Noncoding Regulatory Mutations As a Driving Event for the Oncogenic Core Regulatory Circuitries of Neuroblastoma

Mario Capasso,Vincenzo Aievola,Vito Alessandro Lasorsa,Annalaura Montella,Ferdinando Bonfiglio, Marianna Avitabile, Teresa Maiorino,Matilde Tirelli, Giuseppe D'Alterio, Matthias Fischer, Frank Westermann,Achille Iolascon

Cancer research（2024）

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摘要

Neuroblastoma (NB) is a pediatric tumor composed of adrenergic (ADRN) and mesenchymal-like (MES) cells which derive from the dysregulation of normal cell differentiation imposed by NB Core Regulatory Circuitries (CRCs) [...]

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关键词

neuroblastoma,genomics,somatic mutations,next-generation sequencing

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