Convergent Paired Electrolysis for the Synthesis of Pyrazolyl‐Substituted Tetrahydroisoquinolines

A convergent paired electrolysis method for the synthesis of 1-pyrazolyl-substituted tetrahydroisoquinolines has been developed. The reaction proceeded without any transition metal catalyst and chemical oxidant. The desired products could be isolated in high yields (80-99%) in 60-80 minutes. The Faradaic efficiency was 108% and gram-scale synthesis (84%) could be carried out. Mechanistic studies revealed that the C-N bond formation process might mainly involve a nucleophilic addition reaction. +image