Exhausted status of tumor-infiltrating CD8 T Cells determine their response to PD-1 blockade in ovarian clear cell carcinoma

Junsik Park,Jung Chul Kim,Miran Lee,JooHyang Lee,Yu Sang Lee,Yong Jae Lee,Sunghoon Kim,Sang Wun Kim,Jung-Yun Lee

GYNECOLOGIC ONCOLOGY（2023）

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摘要

Recent clinical trials have demonstrated the potential efficacy of immune checkpoint inhibitors (ICIs) for ovarian clear cell carcinoma (OCCC). However, little is known about the immune characteristics of OCCC. In this study, we investigated the immunologic properties of tumor-infiltrating lymphocytes (TILs) in patients with OCCC to elucidate therapeutic responses to ICIs.

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ovarian clear cells carcinoma,tumor-infiltrating

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