Effect Of Aspirin And Statins On Pulmonary Function And Inflammation In Patients With Aecopd

Background: The influence of coronary atherosclerosis and related treatment drugs on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) development requires in-depth study. The study investigated the effect of coronary artery calcification (CAC) and drugs for CAC on the development of AECOPD.Methods: This retrospective clinical study recruited subjects with AECOPD from May 2017 to May 2019. All subjects performed spirometry and coronary computed tomography (CT), and were divided into three groups according to whether coronary CT revealed CAC and whether they had received oral aspirin and statins: AECOPD group, AECOPD+CAC nonmedication and AECOPD+CAC medication. The t-test and nonparametric test were used for analyzing the lung function, arterial blood gas, routine blood and lipid between groups.Results: Compared with the AECOPD group, Lym% were significantly higher (P=0.033) in both the AECOPD+CAC nonmedication and the AECOPD+CAC medication. The AECOPD+CAC medication group also had significantly higher PaO2 (P<0.05). WBC, Neu, and Neu% in the AECOPD+CAC medication group were significantly lower (P<0.05) compared to the AECOPD group.Conclusions: Aspirin and statins for the treatment of cardiovascular diseases may be linked to improving lung function, normalizing blood gas levels, and reducing inflammation in patients with AECOPD and CAC. Further, randomized controlled trials are needed to explore this topic.