Inside Cover: Synthesis of Alternating Polyisocyanate Copolymers by Anionic Polymerization for Mimicking Amphiphilic Helical Peptides (Angew. Chem. Int. Ed. 51/2022)

In the synthesis of alternating polyisocyanate copolymer by anionic polymerization, the (S)-(−)-α-methylbenzyl isocyanate and allyl isocyanate are incorporated into anionic propagation sites in an alternating fashion. The ammonium thiols are introduced to the allyl group to achieve the Janus amphiphilic helical conformation of polyisocyanate. Polyisocyanate mimics the structure and antibacterial activity of amphiphilic helical peptides, as described by Jiwon Seo, Eunji Lee, Jae-Suk Lee, and co-workers in their Research Article (e202212398).