Soluble OX40 is significantly increased in the serum of overweight and obese patients with type 2 diabetes

Abstract Object : Our study mainly aimed to explore the presence of sOX40 in the peripheral serum of overweight and obese patients. Methods : 60 overweight and obese patients admitted to the endocrinology department of the first affiliated hospital of Soochow University were recruited into the study and divided into control group (25 participants) and T2DM group (35particpants) according to the World Health Organization diagnostic criteria. The differences of general statistics, biochemical parameters, islet function and sOX40 were compared among the two groups. The associations between HbA 1C and other parameters and the influences of various parameters on the severity of hyperglycemia were analyzed. Results : Serum levels of OX40 was significantly higher in T2DM group compared with control group(p＜0.05). Pearson correlation analysis showed that HbA 1c was positively correlated to sOX40 and FBG and negatively correlated to BMI, 2hINS, FCP and 2hCP( P <0.05). Multiple linear regression analysis showed significant positive influences of sOX40 and FBG on hyperglycemia in overweight and obese patients ( P <0.05). Conclusion : Hyperglycemia in overweight and obese patients increased with sOX40. Higher sOX40 was the independent risk factors for hyperglycemia in overweight and obese patients.