The origin of heavy elements from iron to uranium in the universe is an important frontier direction for nuclear astrophysics. It is considered to be one of the 11 greatest unanswered questions of physics in this century. The neutron capture reaction can overcome the Coulomb barrier and is the key way to generate heavy elements in the universe. The average life of free neutrons is only about 15 min. Therefore, the neutron source is a hot topic for understanding the origin of heavy elements. There are two main neutron sources in the s-process nucleosynthesis, one is the 13C(α, n)16O reaction, the other is the 22Ne(α, n)25Mg reaction. The 13C(α, n)16O reaction mainly provides neutrons for the s-process nucleosynthesis of small or medium mass stars, and affects the nucleosynthesis of nuclides with the mass numbers from 90 to 209; while the 22Ne(α, n)25Mg reaction mainly provides neutrons for the s-process nucleosynthesis of massive stars and affects the nucleosynthesis of nuclides with the mass number less than 90. The 22Ne(α, n)25Mg reaction takes place in the core helium burning phase and the subsequent shell carbon burning phase of massive stars. Due to the difficulty of experiment measurement, the data of the 22Ne(α, n)25Mg reaction rate is still lacking, which leads to the problem of understanding effective neutron supply in the nucleosynthesis of the heavy elements in massive stars. Limited by cosmic ray backgrounds, a large number of key reactions in hydrostatic nuclear burning phases cannot be accurately measured. Therefore, direct measurement of these reactions has gradually moved from the earth-surface to underground laboratories. The Laboratory for Underground Nuclear Astrophysics (LUNA) experimental platform in Italy is a mature underground nuclear astrophysics laboratory in the world. Since the 1990s, direct measurement of many nuclear reactions has been carried out. Jinping Underground Nuclear Astrophysics Laboratory (JUNA) is a new experimental platform. JUNA is located in the world’s deepest underground laboratory—China JinPing Underground Laboratory (CJPL). JUNA team has successfully developed a 10 mA low-energy accelerator and experimental terminal, which aims to conduct experimental research on a number of key nuclear reactions in hydrostatic hydrogen and helium burnings of stars in an underground environment with very low background. Since its operation in the underground laboratory at the end of 2020, JUNA has completed the first phase of experimental tasks and successfully studied several key nuclear reactions including the neutron source reaction 13C(α, n)16O. In this paper, we review the motivation of the key neutron source 22Ne(α, n)25Mg in the origin of heavy elements and in the massive stars, the latest research progress of this neutron source and future research plan, especially the underground direct measurement experimental plan. As the key neutron source reaction of the s-process, the 22Ne(α, n)25Mg reaction is of great significance for understanding the origin of heavy elements in the universe. As the first experiment in the second phase of JUNA, the 22Ne(α, n)25Mg reaction is expected to achieve world-class research results and provides the crucial nuclear input for understanding the nucleosynthesis in weak s-process.
