Peripheral direct current suppresses physiologically evoked nociceptive responses at the spinal cord in rodent models of pain

Abstract Electrical neuromodulation is an established non-pharmacological treatment for chronic pain. However, existing devices using pulsatile stimulation are not suitable for all types of chronic pain. Direct current stimulation is a recently developed technology which shows better selectivity for small-diameter fibres. We investigated if this selectivity could be applied to preferentially suppress nociceptive signalling. We applied direct current to the sciatic nerve of rats and compared its effects on spinal activity produced by physiological (non-electrical) stimuli delivered to the foot. Tests were performed across models of neuropathic and inflammatory pain to further clarify potential clinical applications. We found that direct current could effectively suppress activity relating to painful stimuli in both pain models tested. These findings strongly support the use of direct current neuromodulation for chronic pain relief, and suggest that it may be effective at treating a broader range of aberrant pain conditions than existing devices.