Lipids, Oxidation, and Cardiovascular Disease

Cardiovascular disease (CVD) remains one of the leading causes of morbidity and mortality worldwide with altered lipid metabolism as an important risk factor. In the current chapter we discuss processes involved in lipid metabolism, the past and emerging roles of various lipoprotein cholesterol molecules in this process, free fatty-acid metabolism and the various mechanisms of lipid oxidation and their impact on vascular physiology in health and disease. We further describe the role of reverse cholesterol transport (RCT) in the elimination of lipids as bile acids, and finally discuss current clinical interventions based on emerging technologies against dyslipidemia, hypertriglyceridemia, and CVD