Measuring the macromolecular baseline in the neonatal brain

The doublet nature of the 3 ppm peak previously reported in neonates indicates that a lower macromolecular contribution to the GABA+ 3 ppm signal is likely to be present in this population. Detailed characterisation of age‐related MM contribution rates is required to improve the MRS fitting process, and therefore, to further increase the accuracy of metabolic measurements in neonates. As a first step, we here measure the macromolecular baseline using metabolite-nulling MRS in healthy term neonatal participants.