Innentitelbild: Engineered Histidine‐Rich Peptides Enhance Endosomal Escape for Antibody‐Targeted Intracellular Delivery of Functional Proteins (Angew. Chem. 38/2023)

A histidine-rich endosomal escape peptide, as described by Juanjuan Du et al. in their Research Article (e202304692), is capable of mediating efficient endosome-to-cytosol transport of peptide/protein cargo, depicted in the cover picture as butterflies escaping from bubbles trapping them. Once combined with antibody-mediated endocytosis, this strategy enables cell-specific cytosolic delivery of functional proteins.