Discovery of a photoactivatable dimerized STING agonist based on the benzo[b]selenophene scaffold

Dongyu Liu,Bin Yu,Xin Yuan Guan, Bin Song,Huikai Pan,Renbing Wang,Xi Feng,Lixia Pan, Hua Huang,Zhe Wang,Hongxi Wu,Zhixia Qiu,Zhiyu Li,Jinlei Bian

Chemical Science（2023）

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摘要

The first photoactivatable STING agonist, caged-diBSP01, is presented based on a novel and potent dimerized STING agonist diBSP01. Caged-diBSP01 allowed spatiotemporal control of STING activation by light, which was well characterized both in vitro and in vivo .

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关键词

sting agonist,photoactivatable

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