The Role of Preoperative CONUT Score in Prognosis in Patients With Radical Cystectomy

Background:We evaluated the prognostic significance of the controlling nutritional status (CONUT) score, which was evaluated preoperatively, on survival.We aimed to evaluate prognostic signifcance of preoperatively assessed controlling nutritional status (CONUT) score on survival in bladder cancer (BC) patients underwent radical cystectomy (RC). Materials and Methods:The clinical and pathological data of 232 patients who underwent RC for BC between January 2006 and January 2019 at a tertiary level hospital were evaluated respectively.The data of the patients participating in the study were collected retrospectively from the patient records.All patients gave consent during hospitalization so that their information could be used.The potential prognostic value of CONUT score was assessed by using ROC curve analysis.The Kaplan-Meier method and Cox regression hazard models were used to analyzed the effect of CONUT score for patients' disease-specifc survival (DSS) and overall survival (OAS).Results: Totally, we had 232 BC patients.Mean age was 62,98 ± 9,3 years.Only 14 (6%) of the patients were female.According to ROC analysis, optimal threshold of CONUT score for DSS was 3,50.In Kaplan-Meier analyses, the high CONUT score group showed worse progression in DSS and OAS (all parameters, p < 0.05).On Cox regression models of clinical and pathological parameters to predict DSS, age (HR 1.04, 95% CI 1.01-1.07;p=0.009),pathological T stage (HR 5.53, 95% CI 2.09-14.46;p< 0.001) CONUT score (HR 5.44,p<0.001);and to predict OAS, only age (HR 1.04, 95% CI 1.01-1.07;p = 0.004) were determined as independent prognostic factors.