A-011 High Sensitive Troponin Assays for Differentiating the Patients with Unstable Angina from Stable Angina

Abstract Background There have been no cardiac biomarkers used in the diagnosis of unstable angina. In this study, we examined high sensitive troponin T and I as a marker to differentiate the patients with unstable angina from the patients with stable angina. Methods A total of 816 patients (59 AMI, 94 unstable angina, 99 stable angina, 623 healthy individuals) were included. All patients had glomerular filtration rate of ≥60 mL/min/1.73 m2. Leftover serum samples were obtained from the patients who visited The Catholic University of Korea, St Vincent’s Hospital from April to November, 2019. Cardiac troponin was measured using Beckman Coulter Access high sensitivity cTnI assay, Abbott Architect high sensitive TnI assay, and Roche Elecsys Troponin T-high sensitive assay. Results The 99th percentile URLs (Upper Reference Limits) of Beckman Coulter cTnI, Abbott cTnI, and Roche cTnT are 9.8 ng/L, 17.9 ng/L, and 16.4 ng/L, respectively. In the 99 patients with stable angina, 9.1% (9/99), 5.1% (5/99), and 6.1% (6/99) of the patients showed higher values than each the 99th percentile URL with Beckman Coulter cTnI, Abbott cTnI, and Roche cTnT, respectively. In the 94 patients with unstable angina, 24.5% (23/94), 24.5% (23/94), and 25.5% (24/94) showed higher values than each the 99th percentile URL with Beckman Coulter cTnI, Abbott cTnI, and Roche cTnT, respectively. There are significant differences between the frequencies of the patients with stable angina and unstable angina showing higher values of cardiac troponins than each the 99th percentile URL. Conclusion High sensitive troponins could be a useful marker for the differentiation of the patients with unstable angina from stable angina.