Pathologically documented brain necrosis: response to bevacizumab after irradiation for solitary fibrous tumour/haemangiopericytoma: case report and literature review

Background: Solitary fibrous tumours/haemangiopericytomas (SFT/HPC) are uncommon vascular mesenchymal tumours. Treatment usually involves surgical resection with or without preoperative embolization, followed by high dose radiotherapy. These tumours are prone to local, distant intracerebral and extracranial recurrences. Cerebral radionecrosis is a not uncommon complication of radiotherapy to the brain. Here we provide the first reported case of radionecrosis post radiotherapy for SFT/HPC, and its successful treatment with bevacizumab, and review the literature on the emerging role of bevacizumab in the treatment of radiation-induced cerebral necrosis.