Should Enlarged Supradiaphragmatic Lymph Nodes be Routinely Removed during Debulking Surgery Procedures for Patients with Advanced Ovarian Cancer?

Complete cytoreduction is the cornerstone of advanced ovarian cancer treatment. The positive impact of no residual disease has been demonstrated even in patients with stage IV disease. Involvement of cardiophrenic nodes (CPLNs), that qualifies as stage FIGO IVB, is common in advanced ovarian cancer. Surgical removal of CPLNs is considered a safe and feasible procedure, requiring a minimal surgical effort associated with a low morbidity. However, data about the impact of CPLN removal on oncologic outcomes are still scarce.