Uracil/H+ Symport by FurE Refines Aspects of the Rocking-bundle Mechanism of APC-type Transporters

Iliana Zantza,Yiannis Pyrris,Stefano Raniolo,Georgia F. Papadaki,George Lambrinidis,Vittorio Limongelli,George Diallinas,Emmanuel Mikros

Journal of Molecular Biology（2023）

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摘要

•Funnel Metadynamics and mutational analysis reveal molecular steps driving symport of uracil/H+ by FurE.•Identified intermediate conformational states in FurE challenge aspects of the mechanism of transport by Mhp1.•Employing H3O+ as a separate ligand leads to a model on how proton symport might drive substrate translocation.

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关键词

aspergillus nidulans,NCS1 transporters,FurE nucleobase-proton symporter,funnel Metadynamics,mechanism of function

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