Skrining Fitokimia dan Aktivitas Antikoagulan Sari Buah Melon (Cucumis melo L) Secara In Vivo

Anticoagulants are drugs used to inhibit the development and enlargement of a blood clot. Melon is known to contain adenosime that function to stop clotting of blood cell chip. This study aims to identify secondary metabolites contained in melon juice, fruit juice identify anticoagulant activity in vivo melon, look for an effective dose melon juice as a potential anticoagulant and melon juice compared with aspirin. A total of 15 male mice were divided into 5 groups, i.e. groups of melon juice dose of 12.9 g/kg BW, melon juice dose group of 25.8 g/kg BW, melon juice dose group of 51.5 g/kg BW, positive control group and negative control group. The sample is given once a day orally and measured in hours to 3, 6 and 9 after administration. Anticoagulant effect was tested by using the parameters of bleeding time and coagulation time. The results showed that the melon juice dose of 12.9 g/kg BW, 25.8 g/kg BW and 51.5 g/kg BW may increase bleeding time and coagulation time. From these results it can be seen that the melon juice has anticoagulant activity. Based on statistical test is known that the variation of doses is very significantly affect on bleeding time and the coagulation time.Keywords : anticoagulant, melon juice, bleeding time, coagulation time