WS09.05 Aggregated genetic modifiers predict lung dysfunction at age 5–6 years in children with cystic fibrosis

Objectives: Non-CFTR genetic modifiers are implicated in lung disease of adults with CF. We recently demonstrated that in addition to CFTR genotype, non-CFTR genetic modifiers evaluated by a composite polygenic risk score (PRS) had a significant impact on development of early-onset lung disease in 1–3 yr-old children with CF. The objective of this study is to test the hypothesis that PRS also predicts lung function at age 5–6 yr.