Exosomal miRNA and mRNA signatures as liquid biomarker for head and neck cancer

Introduction Exosomes are small extracellular vesicles that mediate intercellular communication. HNSCC patient’s plasma is enriched in immunomodulatory exosomes which correlate with clinical parameters. In this study we compare for the first time miRNA and mRNA signatures of plasma-derived exosomes and corresponding tumor cells in order to evaluate their potential biomarkers for HNSCC.