Evaluation of Physico-Phytochemical Parameters of Holarrhena Pubescens Wall.Ex G. Don. (Kutaja) Seed and Bark and Their Effect in Obesity Associated Hyperlipidemia

Obesity-related Hyperlipidemia is a major health concern due to its strong association with a number of diseases like diabetes, ischemic heart disease,and renal disease. The safe treatment of Hyperlipidemia thus becomes the need of the hour. This study aimed to evaluate the pharmacognostic, physicochemical,with phytochemical properties of Holarrhenapubescens Wall.ex G. Don. (Kutaja) seed and bark. The pharmacognostic, physicochemical, and phytochemical evaluationof collected samples of H. pubescens seeds and bark was performed and was found to be as per API norms. Furthermore, to evaluate and compare their efficacyin the treatment of Hyperlipidemia. - Forty subjects were randomly allocated to two groups according to the plant part administered to them and was observedfor 90 days. The assessment was done on the basis of subjective parameters (Laziness, heaviness of body, Shortness of breath, and sleepiness) and objectiveparameters (total cholesterol, triglycerides, LDL, HDL, VLDL, and total Cholesterol to HDL ratio) before and after the treatment duration. - Significant decreasein the subjective parameters was recorded, and similarly, a significant decrease in the levels of total cholesterol, LDL, VLDL, and total Cholesterol to HDL ratiowas observed for both the seed and the bark of Kutaja – The therapeutic effect of both the parts i.e. Kutaja seeds and bark were found at par in controllingHyperlipidemia and thus proved their definite role in ameliorating Medodustii.e. deranged lipid metabolism common in Obesity.– Both seeds and bark can be utilizedseparately and also in place of one another in cases of Obesity associated Hyperlipidemia.