Supplementary Figure 6 from Akt Inhibitors MK-2206 and Nelfinavir Overcome mTOR Inhibitor Resistance in Diffuse Large B-cell Lymphoma

PDF file - 24K, Vinblastine does not synergize with Rapamycin in SU-DHL 4 cell line. A-B. Approximately 106 cells/ml of SUDHL-4 and SUDHL-6 were treated with Rapamycin, Vinblastine, and the combination of both drugs (all doses lower than IC50 for each drug), for 48h. Viability was assessed by a fluorometric resazurin reduction assay. Each experiment was performed in octuplicate, and repeated twice. Shown here are representative results. C-D. Combination indices for the effects of combination of Rapamycin and Vinblastine on viability, as determined using the Chou-Talalay equation, are shown.