Supplementary Figures S1-S5 from The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis

Supplementary Figures S1-S5. Supplementary Figure S1: Structures of Pt-DNA adducts. Figure S2: Histogram of HCT116 p53+/+ cells treated with oxaliplatin or cisplatin. Figure S3: (A) p53 and p21 induction by oxaliplatin. (B) Identification of the mitochondria isoform of dUTPase (DUT-M). Figure S4. Related to Figure 4 A-C. Pri-miR-34a induction (A), downregulation of DUT transcript (B) and changes in the amount of proteins (C) by oxaliplatin. Figure S5. Related to Figure 5E. (A) Ectopic expression of TK1-3xFLAG, (B) Histogram of HCT116 p53+/+ cells with transient TK1-3xFLAG expression and oxaliplatin treatment.