P-627 Effects of ntraovarian Injection of Autologous Platelet-Rich Plasma on Ovarian Reserve in Poor Responders undergoing IVF Treatment

Abstract Study question Does intracortical injections of autologous platelet-rich plasma (PRP) improve the outcomes in patients with poor ovarian response (POR) undergoing the IVF treatment? Summary answer PRP injections could improve the markers of low ovarian reserve, especially the first month after the injection. What is known already Poor ovarian responders (PORs) with poor reproductive outcomes during the IVF treatment is considered the main challenges of reproductive science. PORs are presented by low ovarian reserve, poor oocyte quality and low response to ovarian stimulation protocols. Despite several approaches that have been investigated to improve the ovulation outcome in PORs, the pregnancy rate remains low. Study design, size, duration The pilot study was designed as prospective observational studies. 39 PORs based on Bologna criteria were included and followed by 3 months. Couples presenting with any other infertility etiology other than POR were excluded. All participants provided written informed consent prior to treatment. Participants/materials, setting, methods The patients in the study were received at least two previous failed Intracytoplasmic Sperm Injection (ICSI)-Embryo Transfer (ET) fresh cycle. PRP intraovarian infusion treatment was performed following the last failed ICSI-ET cycle. The patients were followed 3 months after the injection. Primary outcome measures were levels of anti-müllerian hormone (AMH), antral follicle count (AFC), follicle stimulating hormone (FSH), and oocyte yield after the PRP treatment. Main results and the role of chance The level of AMH was significantly elevated from 0.52±0.43ng/ml before the PRP treatment to 0.82±0.61ng/ml after the treatment. The AFC showed the same trend from 2.52±1.50 to 5.83±4.25 and the FSH level was decreased by 31.98%. But the number of retrieved oocytes and embryo available were not significantly increased. Limitations, reasons for caution The design of the observational studies and the small sample size. Wider implications of the findings PRP injection may be a potiental treatment for PORs in IVF. Trial registration number not applicable